PEPTIDES·INDEX
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DihexaNootropic

Peptide studied for synapse formation and memory.

Rating1/5SpeculativeHuman dataSafety
Compare prices — from $94.50
StatusResearch only
FDA-approvedNO
PrescriptionNO
From$94.50

Overview

Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) is a small, chemically modified peptide derivative of angiotensin IV, designed at Washington State University to be orally active and to cross the blood-brain barrier. It has been researched for memory and synapse formation in rats and mice only (scopolamine, aged-rat and APP/PS1 Alzheimer's models); no human study has ever been published. The evidence base is also shakier than it looks: the 2014 paper proposing its HGF/c-Met mechanism was retracted in 2025, and the 2013 discovery paper carries an expression of concern. Dihexa is not FDA-evaluated and is sold as a research chemical only; nothing here is medical or dosing advice.

Related compounds

Methylene BlueNootropicResearch compound studied for mitochondrial and cognitive effects.SemaxNootropicNootropic peptide studied for cognition and recall.PinealonNootropicPeptide bioregulator studied for brain function.SelankNootropicAnxiolytic peptide studied for calm focus.

Sources

Starting references for the library summary. These are not dosing instructions or medical advice.

Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agentsJournal of Pharmacology and Experimental Therapeuticspubmed.ncbi.nlm.nih.gov/23055539/…Retraction notice to "The Procognitive and Synaptogenic Effects of Angiotensin IV-Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System"Journal of Pharmacology and Experimental Therapeuticspubmed.ncbi.nlm.nih.gov/40312093/…AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling PathwayBrain Sciencespubmed.ncbi.nlm.nih.gov/34827486/…

For research-use educational context only. Not medical advice and not a recommendation to use any compound. Consult a qualified healthcare professional before any health decision.