PEPTIDES·INDEX
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Library

PNC-27

p53-derived membrane-active peptide studied in cell and mouse cancer models.

Rating1/5SpeculativeHuman dataSafety
Compare prices — from $63.00
StatusResearch only
FDA-approvedNO
PrescriptionNO
From$63.00

Overview

PNC-27 is a 32-residue synthetic peptide that joins the HDM-2-binding region of p53 (residues 12-26) to a cell-penetrating "penetratin" sequence. In cell cultures and mouse models it binds HDM-2 displayed on cancer-cell membranes and punches pores that kill those cells, while sparing the normal cells tested. No human trial has been published, so none of this shows it is safe or effective in people. It is not FDA-evaluated and is sold for laboratory research only; nothing here is medical or dosing advice.

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Sources

Starting references for the library summary. These are not dosing instructions or medical advice.

Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranesProceedings of the National Academy of Sciences of the United States of Americapubmed.ncbi.nlm.nih.gov/20080680/…Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemiaLeukemiapubmed.ncbi.nlm.nih.gov/31337857/…PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell LysisBiomedicinespubmed.ncbi.nlm.nih.gov/35625682/…

For research-use educational context only. Not medical advice and not a recommendation to use any compound. Consult a qualified healthcare professional before any health decision.