PEPTIDES·INDEX
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Library

O-304Metabolic / Exercise Mimetics

Pan-AMPK activator studied for blood sugar and exercise capacity; a small molecule, not a peptide.

Rating2/5Early-SignalHuman dataSafety
Compare prices — from $162.00
StatusResearch only
FDA-approvedNO
PrescriptionNO
From$162.00

Overview

O-304 (O304) is a synthetic small molecule — not a peptide — that activates AMPK, the cell's energy sensor, developed by the Swedish company Betagenon. It has been researched for blood-sugar control, blood flow and heart function and as an "exercise mimetic", mainly in mice; the only human data is a small proof-of-concept phase IIa trial in people with type 2 diabetes on metformin, reported by the developer, in which fasting glucose and insulin resistance improved. That is early, limited evidence, not an established effect. It is not FDA-evaluated and is sold for laboratory research only; nothing here is medical or dosing advice.

Related compounds

SLU-PP-332 TabletsMetabolic / Exercise MimeticsERR agonist studied for metabolism and endurance.SLU-PP-915Metabolic / Exercise MimeticsOrally active ERR agonist studied in mice as an exercise mimetic; a small molecule, not a peptide.

Sources

Starting references for the library summary. These are not dosing instructions or medical advice.

PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patientsJCI Insightpubmed.ncbi.nlm.nih.gov/29925691/…AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged miceCommunications Biologypubmed.ncbi.nlm.nih.gov/34795407/…

For research-use educational context only. Not medical advice and not a recommendation to use any compound. Consult a qualified healthcare professional before any health decision.